Damaged base recognition involves three discrete enzyme DNA complexes. The search complex (SC) is a loose nonspecific complex that is competent for hopping and ...
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Jan 16, 2024 · The NER (nucleotide excision repair) mechanism is employed to repair the damage by creating large adducts and intra-strand crosslinks when UV ...
Most damage to bases in DNA is repaired by the base excision repair (BER) pathway [1]. BER is initiated by DNA glycosylases, enzymes that recognize specific ...
Sep 7, 2020 · Efficient search for DNA damage embedded in vast expanses of the DNA genome presents one of the greatest challenges to DNA repair enzymes.
Here we applied a chemical disulfide crosslinking method to probe the damage-searching mechanism of two O6-alkylguanine-DNA alkyltransferases, the Escherichia ...
Base excision repair of genotoxic nucleobase lesions in the genome is critically dependent upon the ability of DNA glycosylases to locate rare sites of ...
Although the AP site DNA lesion is repaired by base excision repair (BER), persistent AP sites can have adverse consequences, posing a challenge to genome ...
Dec 30, 2022 · Historically, transient DPCs have been shown with a number of DNA repair enzymes with DNA glycosylase or AP-lyase activities (2,4). The ...
Jan 6, 2015 · The structure shows that a disulphide-tethered Rad4 flips out normal nucleotides and adopts a conformation similar to that seen with damaged DNA ...
Notably, the DNA damage repair occurs in the context of chromatin, a higher-ordered structure composed of DNA wrapped around histone proteins and stabilized by ...